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  • Diphenhydramine topical (brand name Benasoothe®) is an antihistamine with some local anesthetic properties. It is used to relieve itching and skin irritation in dogs, cats, and other animals. Diphenhydramine topical comes in a variety of forms, which may be specially compounded.

  • Diphenoxylate + atropine (brand name Lomotil) is an opioid combination medication used to treat diarrhea or coughing in dogs and diarrhea in cats. Its use in cats is not generally recommended. Diphenoxylate + atropine is given by mouth in the form of a tablet or liquid. This article discusses administration, potential side effects, risks, and monitoring.

  • Ear cleansing/drying products are used over-the-counter to treat and prevent ear infections in many species of pets. They come as a liquid solution that is used topically within the ear canal and are typically used in the ears after debris and wax have been removed using a cerumenolytic cleanser.

  • Emodepside/praziquantel (brand name Profender®), is an antiparasitic drug used to treat and control hookworms, roundworms, and tapeworms in cats. Empodepside with praziquantel comes in topical solution form that is applied directly to the skin.

  • Many veterinarians, including nutritionists and behaviorists, believe it is important for dogs and cats to express their natural foraging and hunting behaviors. For pets living indoors, this can be difficult, and the lack of this stimulation can sometimes lead to behavior problems. Enriching a pet's environment with food toys and puzzles at mealtimes can fulfill the need to forage. The use of toys, puzzles and other novel methods of food delivery can also be effective ways to increase daily movement in overweight or inactive pets.

  • Enzymatic toothpaste (brand name C.E.T., others) is a product used at home by pet owners to aid in tooth brushing that minimizes plaque and tartar formation on the exterior of the tooth (the crown), and also assists in the maintenance of good oral hygiene. It can be used on both dogs and cats.

  • Epineprhine is a drug used most often in emergency situations for animals (e.g., anaphylaxis, cardiopulmonary resuscitation/CPR). It may be added to local anesthesia drugs due to its ability to cause veins to constrict, thus delaying the body’s absorption of the drugs and prolonging the duration of the local anesthetic duration.

  • Eprinomectin + praziquantel (brand name Centragard®) is a topical (spot-on) antiparasitic drug used to treat and control hookworm, roundworm, and tapeworm infections, and to prevent heartworm disease in cats and kittens that are at least 7 weeks of age and weigh at least 0.8 kg (1.8 lb). Do not use in cats known or suspected to have two copies of the MDR1 gene mutation.

  • Erythromycin ophthalmic is an antimicrobial medication used to treat certain types of eye infections. It may be used “off label” or “extra label” to treat other eye conditions. Erythromycin ophthalmic comes in ointment form. Caution when using this medication in pocket pets as fatal diarrhea may occur if ingested orally.

  • Esafoxolaner + eprinomectin + praziquantel is given topically on the skin to treat and protect against various internal and external parasites and prevent heartworm in cats. Side effects are rare but may include hair loss at the application site, gastrointestinal upset, skin reactions, or neurologic signs. Use caution in sick or underweight cats. If a negative reaction occurs, please call your veterinary office.